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KMID : 0361019950380060855
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Korean Journal of Otolaryngology - Head and Neck Surgery
1995 Volume.38 No. 6 p.855 ~ p.861
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Control of Drug Delivery in Fibrin-Antibiotic Mixture
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Abstract
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Systemic administrations of antibiotics are most commonly used modes of treatment in management of otitis media, but adequate tissue concentration of antibiotics cannot be always achieved. In contrast, topical use of antibiotics can include high
level
of tissue concentration, but it cannot be maintained for a long time. In order to improve the therapeutic effect of antibiotics in the middle ear, a fibrin-based drug delivery system was designed and in vitro efficacy was evaluated.
Four kinds of fibrin clot were made using Ampicillin, Gentamycin and Ofloxacin respectively and biologic assay was performed using Bacillus Subtilis. All three antibiotics tested were found to be released more slowly from the
fibrin-gelatin-antibiotic
mixture than fibrin-antibiotic mixture. Especially Gentamycin group demonstrate antibiotic activity up to 120hours against Bacillus Subtilis. This results suggest the possibility of clinical application of this new device. (Korean J Otolaryngol
38:6,
1995)
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